The Relationship of Cathelicidin Antimicrobial Peptide and Vitamin D during COVID-19 Pandemic

  • Natasha Dianasari Devana Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Ninik Mudjihartini Departement of Biology Molecular and Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Keywords: Peptida Antimikrobial, Cathelicidin, Vitamin D, COVID-19

Abstract

A peptide known as antimicrobial peptide (AMP) possesses antimicrobial effects against bacteria, fungus and viruses. AMP, also known as Host Defense Protein (HDP), is one of the body's defense mechanisms since it has the capacity to actively kill viruses. When it comes to respiratory cells, which are the major target of the SARS CoV-2 virus that produces COVID-19, cathelicidin, a kind of AMP in humans, is known to have protective properties. Cathelicidin AMP performance represents the first-line action of the natural immune system, with cathelicidin synthesis linked to appropriate vitamin D levels. Numerous earlier studies have discovered a connection between low cathelicidin levels and low vitamin D levels; this underlines the significance of vitamin D levels in strengthening the immune system. Naturally, particularly for the production of cathelicidin, which serves as the body's primary line of defense during the COVID-19 pandemic.

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Published
2023-02-04
How to Cite
Devana, N. D., & Mudjihartini, N. (2023). The Relationship of Cathelicidin Antimicrobial Peptide and Vitamin D during COVID-19 Pandemic. Journal Of The Indonesian Medical Association, 72(6), 259 - 265. https://doi.org/10.47830/jinma-vol.72.6-2022-923
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