Journal Of The Indonesian Medical Association <p>Journal Of The Indonesian Medical Association (JInMA) atau Majalah Kedokteran Indonesia (MKI) merupakan jurnal ilmiah kedokteran yang berada dibawah naungan Pengurus Besar Ikatan Dokter Indonesia (PB IDI) dan jurnal terakreditasi Kemenristek DIKTI.&nbsp;</p> <p>MKI JInMA memuat beberapa tipe artikel yaitu artikel penelitian, laporan kasus,<em> evidence-based case reports</em> (EBCR), tinjauan pustaka, dan editorial.</p> <p>MKI JInMA saat ini terbit dengan frekuensi per dua bulan.&nbsp;</p> <p>&nbsp;</p> en-US (Evi Suprapti, Amd.RS, S.E) (Evi Suprapti, Amd.RS., S.E) Mon, 21 Nov 2022 16:30:37 +0700 OJS 60 Psychoneuroimmunological Aspect of Type 2 Diabetes Mellitus <p>Diabetes is a chronic disease which included in the 10 major leading causes of death globally. Pathogenesis of DM 2 involves complex mechanisms in various organs. Psychological conditions including stress, anxiety, and depression considered to be reciprocally related to impaired glucose regulation. On the other hand, hyperglycaemia in DM 2 may triggers some psychological disorder. Chronic psychological disorders activate the HPA axis, causing cortisol level elevation and disrupt its negative feedback mechanism. Other factors involved in disturbance of glucose regulation due to psychological distress were sympathetic nervous system, inflammatory and oxidative stress pathways, tryptophan metabolism and gut microbiota dysbiosis. These factors were interrelated to form a vicious cycle causing progression and complications in DM 2.</p> Ariana Setiani, Gusti Ayu Maharatih, Supriyanto Kartodarsono Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 10:08:00 +0700 Relationship Of Body Fat And Hematoma Volume Of Intracerebral Hemorrhagic Stroke <p><em><strong>Introduction</strong>: Body fat percentage (%BF) can be easily and accurately predicted by measuring skinfold thickness. So that the distribution, relationship, and prediction with the hematoma volume of patients with intracerebral hemorrhagic (ICH) stroke are interesting to study.</em><br><em><strong>Method</strong>: An analytic cross-sectional study of subjects with ICH stroke at Prof. Dr. R.D Kandou General Hospital, Manado, Indonesia who met research criteria consecutively measured the thickness of body skinfolds then converted to %BF and estimated hematoma volume using the ellipse method was examined by linear regression analysis.</em><br><em><strong>Result</strong>: A total of 165 samples (87 men) with a mean age of 53 years. 65% sample had %BF &gt;25% (median 27.8%). &gt;50% men had %BF &gt;25%, 60% women had %BF &gt;30% (p&lt;0.001). The median ICH stroke hematoma volume was 20.5mL (IQR 8.6−43.2mL). There is an increase in the volume of ICH stroke hematoma, especially in men with %BF &gt;30%. In this group, each increase in %BF would increase the volume of ICH stroke hematoma by 22.34mL (95% CI 5.15−39.52mL; p=0.011).</em><br><em><strong>Conclusion</strong>: There was a significant relationship between %BF assessed with skinfold thickness and the volume of ICH stroke hematoma in this study, volume increase was evident especially in men with %BF &gt;30%.</em></p> Eudon Muliawan, Mieke Actress Hanna Nelly Kembuan, Melke Joanne Tumboimbela Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 00:00:00 +0700 Comparison of Respiratory Specimen Culture Results on Sloped Agar and Plate in the Parasitology Laboratory, Faculty of Medicine, Universitas Indonesia <p><em><strong>Introduction</strong>: One of the main health problems in Indonesia is respiratory disease. Respiratory disease can be caused by fungus, so-called lung mycosis. The fungi species that cause respiratory infections in humans range from Candida sp. to more dangerous species such as Aspergillus fumigatus. Culture methods using respiratory specimens, especially sputum, can be used to identify species of fungi that cause pulmonary mycosis. Aim this study was conducted to compare the culture results between conventional culture methods on sloped agar and high volume culture method on plate.</em><br><em><strong>Method</strong>: This study used a cross-sectional design in which the data of culture results were obtained from different culture methods.</em><br><em><strong>Result</strong>: High volume culture method grew more colonies including Aspergillus fumigatus than conventional culture method which grew no Aspergillus fumigatus. The correlation of data between culture methods and culture results were analyzed with McNemar test and it showed p=0.000.</em><br><em><strong>Conclusion</strong>: The relationship between the culture method and culture results has a significant correlation (p&lt;0.05). Therefore, high volume culture was a better method to grow more fungal colonies including Aspergillus fumigatus than conventional culture methods.</em></p> Jason Theola, Mulyati Mulyati, Anna Rozaliyani, Ridhawati Ridhawati, Robiatul Adawiyah Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 11:12:03 +0700 Constant Malaria Transmission From Migrating Humans Residing In Low Endemic Areas <p><em><strong>Introduction</strong>: Malaria is an infectious disease that continues to be a public health issue worldwide, including in Indonesia. This study aims to detect the presence of Plasmodium parasites among immigrants from malaria endemic areas. <br><strong>Method</strong>: The research was conducted from September until November 2019 in three regency/cities in South Sulawesi, namely Makassar City, Tana Toraja and North Toraja. The population in this study were immigrants from malaria endemic areas (native Papua and non-Papua) who lived in the area for at least 2 years before visiting the cities of Makassar, Tana Toraja, or North Toraja. All samples were examined for malaria parasites using Polymerase Chain Reaction (PCR). <br><strong>Results</strong>: The results of the PCR test on 256 samples of migrants (native Papuan and non-Papuan) detected 19.53% positive for malaria. This research showed that a high prevalence of malaria parasites was found among asymptomatic immigrants, both native Papuans and non-Papuans in South Sulawesi. <br><strong>Conclusion</strong>: It can be concluded that the asymptomatic immigrants from endemic areas such as Papua need to be screened early because they may still have malaria parasites in their blood and become carriers, leading potential to cause local transmission.</em></p> Risma Malasari, Nur Rahma, Sri Nur Rahmi Nur Rustam, Rizalinda Sjahril, Isra Wahid Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 11:24:18 +0700 Comparison of Regular Rehabilitation Program with Additional Reciting Holy Qur’an on Cardiorespiratory Fitness among Covid-19 Survivors <div class="page" title="Page 1"> <div class="layoutArea"> <div class="column"> <p><em><strong>Introduction</strong>: Rehabilitation program has been proven to be able to restore the cardiorespiratory function of Covid-19 survivors. Reciting Holy Qur’an are associated with a more relaxed and lowered heart rate of the reciter. The present study aims to compare the regular rehabilitation program with addition of Reciting Holy Qur’an on cardiorespiratory fitness among moslem Covid-19 survivors. </em><br><em><strong>Method</strong>: This quantitative experimental study involved 18 moslem patients who were assigned into two groups. Eight patients in the interventional group received additional Qur’an recitation every day at least 20 pages, divided into several sessions according to the participants’ ability and opportunity. Meanwhile, ten patients in the control group received regular rehabilitation programs with mild to moderate intensity. The cardiorespiratory fitness level was evaluated by a count test (CT), incentive spirometry test (IST), and a 6-minute walk test (6MWT). The measurement was performed three times: before intervention, the first week, and the second week after treatment. </em><br><em><strong>Result</strong>: The participants were eight males and ten females with an age average of 51.9 ± 9.5 years. Both groups showed significant differences before and after treatment in the first and second week in terms of CT, IST, and 6MWT (p &lt;0.05). There was a significant difference between the two groups in the first week in the IST result (p &lt; 0.05), no significant difference in the second week was noticed. </em><br><em><strong>Conclusion</strong>: The Covid-19 survivors receiving additional Holy Qur’an recitation exhibit faster cardiorespiratory fitness improvement than the control group.</em></p> </div> </div> </div> Rita Vivera Pane, Adyan Donastin, Aufar Zimamuz Zaman Al Hajiri Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 11:37:36 +0700 Rhabdomyolysis in Thyroid Crisis <p><em><strong>Introduction</strong>: Hyperthyroidism might lead to rhabdomyolysis. Rhabdomyolysis in thyroid crisis is very rare, currently there are only 7 cases in the world. This is the eight cases in the world that had been reported.</em><br><em><strong>Cases</strong>: We reported a case of a 46-year-old man with Graves’ Disease who presented with thyroid crisis and rhabdomyolysis.</em><br><em><strong>Discussion</strong>: The patient came with shortness of breath and palpitations for 10 hours before admission. Tachycardia, tachypnea, thyroid enlargement, motoric weakness, and bilateral lung crackles were noted. The Burch-Wartofsky Point Scale was 60 and the Japan Thyroid Association grade was TS2 first combination. Laboratory showed hyperkalemia (7.7 meq/L), increase in urea (144 mg/dl), creatinine (1.92 mg/dl), fT4 (&gt;5.0), TSHs (0.06 uIU/ml) creatine kinase (3645 U/L), positive TRAb and Anti-TPO. The patient was treated with thyroid crisis management (propylthiouracil, lugol, dexamethasone) and supportive treatment (dobutamine, digoxin, furosemide, antibiotics, hyperkalemia therapy). After hospitalized for 11 days, the patient was discharged with resolution clinical symptom and levels of CK, urea, and creatinine. </em><br><em><strong>Conclusion</strong>: Hyperthyroidism might lead to rhabdomyolysis. This condition needs to be recognized and becomes a differential diagnosis in non-traumatic rhabdomyolysis accompanied by acute kidney injury. Therefore, can lead to appropriate and prompt management.</em></p> <p>&nbsp;</p> Nanny Natalia Mulyani Soetedjo, Luse Loe, Maya Kusumawati, Ervita Ritonga, Hikmat Permana Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 11:45:31 +0700 The Use of Tumor Necrosis Factor Alpha Inhibitors in Dermatology <p><em>Tumor necrosis factor-α (TNF-α) merupakan sitokin pleiotropik penting pada patogenesis berbagai kelainan inflamasi dalam bidang dermatologi. Beberapa contoh penyakit tersebut adalah psoriasis, hidradenitis supuratif, dermatosis neutrofilik, sarkoidosis, granuloma anulare, toxic epidermal necrolysis, penyakit Behçet, pitiriasis rubra pilaris, skleroderma, sklerosis sistemik, dan eritema nodosum leprosum. Penggunaan anti TNF-α menjadi strategi terapi untuk menghambat progresivitas berbagai penyakit tersebut. Terdapat lima anti TNF-α yang telah diuji secara klinis, yaitu etanercept, adalimumab, certolizumab pegol, infliximab, dan golimumab. Masing-masing obat memiliki profil farmakologi, indikasi, serta efikasi yang berbeda untuk setiap penyakit. Penggunaan anti TNF-α juga berisiko menimbulkan berbagai efek samping, baik bersifat lokal maupun sistemik, termasuk secara paradoks meningkatkan risiko psoriasis.</em><br><br></p> Novita Suprapto, Endi Novianto, Aida Sofiati Dachlan Hoemardani Copyright (c) 2022 Journal Of The Indonesian Medical Association Mon, 21 Nov 2022 12:07:20 +0700