Overview of Post-COVID-19 Multisystem Inflammatory Syndrome in Children

  • Yogi Prawira Child Health Department, Faculty of Medicine Universitas Indonesia/ Dr.Cipto Mangunkusumo General National Hospital, Jakarta
  • Nicodemus Nicodemus Pediatric Intensive Care Unit Mayapada Hospital South Jakarta
Keywords: multisystem inflammatory syndrome in children, severe acute respiratory syndrome coronavirus 2, coronavirus 2019

Abstract

Coronavirus disease (COVID-19) caused by infection of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in December 2019. Since then, many countries have started reporting a series of cases in children post COVID-19 infection, with various clinical manifestations, i.e: persistent fever, cardiovascular shock, and hyperinflammation similar with Kawasaki disease and/or toxic shock syndrome. The terminology Pediatric Inflammatory Multisystem Syndrome Temporarily Associated with SARS-CoV-2 (PIMS-TS) was given by the Royal College of Paediatrics and Child Health (RCPH), hence commonly known as Multisystem Inflammatory Syndrome in Children (MIS-C) as named by the Centers for Disease Control (CDC) and the World Health Organization (WHO). Multisystem Inflammatory Syndrome in Children has a very wide spectrum of clinical signs and symptoms, with the most common symptoms reported is persistant fever, along with gastrointestinal, cardiovascular and dermatological symptoms. Fever is reported in 97-100% of patients. Gastrointestinal symptoms are the second most common symptom occurring in 70% of patients. Until now, the pathogenesis underlying the occurrence of MIS-C is still unknown. Multisystem Inflammatory Syndrome in Children case management requires multidisciplinary knowledge. Consensus or standard guideline for the management of MIS-C is a work in progress, but in general, the initial management includes intravenous immunoglobulin (IVIG) and corticosteroids.

Downloads

Download data is not yet available.

Author Biography

Yogi Prawira, Child Health Department, Faculty of Medicine Universitas Indonesia/ Dr.Cipto Mangunkusumo General National Hospital, Jakarta

Pediatric Intensive Care Unit, Mayapada Hospital Jakarta Selatan, Jakarta

 

Published
2022-10-21
How to Cite
Prawira, Y., & Nicodemus, N. (2022). Overview of Post-COVID-19 Multisystem Inflammatory Syndrome in Children . Journal Of The Indonesian Medical Association, 72(4), 196 - 206. https://doi.org/10.47830/jinma-vol.72.4-2022-800
Viewer: 326 times
PDF (Bahasa Indonesia) downloaded: 394 times