The Role of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio and Relative Eosinophil Count in Atopic Dermatitis Patients

Abstract

Introduction: Atopic Dermatitis (AD) is an inflammatory skin disorder characterized by chronically relapsing inflammation accompanied by pruritus and itching. Inflammatory mechanism and many body immune responses are involved in AD. There are several diagnostic tests to diagnose AD. NLR, MLR and relative eosinophil count are parameters that can be obtained easily and cheap from the economic side. The purpose of this study is to determine the role of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and relative eosinophil count in AD patients with analyzing the sensitivity and specificity.
Methods: This research is done by a cross-sectional method with peripheral blood smear. The number of sample taken were 61 patients with AD who had fulfilled the inclusion and exclusion criteria and 61 healthy controls. The data is then analyzed using Komolgorov-Smirnov and Saphiro-Wilk normality test, Independent T test, Mann-Whitney U.
Result: The data analysis result shows a not statistically significant relationship between NLR in AD patients and healthy controls, p=0,858. This study also shows a significant relationship between MLR and relative eosinophil count in AD patients and healthy controls with p=0,000 and p=0,013. The cut-off point of MLR and relative eosinophil count each are less than 0,0488 (sensitivity 70,5%, specificity 72,1%, AUC 72,5%) and greater than 2,25 (sensitivity 70,5%, specificity 77%, AUC 78%).
Conclusion: MLR and relative eosinophil count can be proposed as diagnostic tools in assisting the diagnosis of AD, however NLR can not be used as AD diagnostic tool