Effects of White Turmeric Extract (Curcuma Zedoaria) as Nephroprotector in Male White Mice Copper-Induced Wistar Strain

Abstract

Background: Metal pollution increases along with increasing industrial development. Exposure to copper in large quantities can cause kidney and liver damage. Curcuma zedoaria has benefits as an antioxidant, anti-inflammatory, antiproliferation, anticancer, and antimicrobial. Curcumin which contained in white turmeric rhizomes in previous studies was used as a nephroprotective variation.
Objective: This study is used to know wether white turmeric rhizome (Curcuma zedoaria had a nephroprotective effect with exposure to CuSO4 pentahydrate.
Methods: This is an experimental study by designing post test only control group design. The sampling is using simple random sampling technique. Male white wistar rats are divided into six groups; normal control, control of white turmeric (45 mg / 200 g), control of CuSO4 pentahydrate, and co-treatment group (curcumin for 14 days followed by CuSO4 for 5 days).
Results: Data were analyzed using One Way test. For group 4 (preventive group) serum urea creatinine level was not different from group 1 and 2 (p greater than 0.05) with mild histological structure damage. However, differences were obtained (p less than 0.05) in Groups 3, 5, and 6.
Conclusion: The dose of 45 mg / 200 g white turmeric extract showed a percentage decrease in serum creatinine urea level and mild histological damage to kidney tissue.