Risk Factor of Intractable in Childhood with Generalized Epilepsy

  • Irawan Mangunatmadja Department of Child Health, Medical School University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Dina Indah Mulyani Department of Child Health, Medical School University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Sudung O Pardede Department of Child Health, Medical School University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Bambang Tridjadja Department of Child Health, Medical School University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta
  • Harjanti F Wulandari Department of Child Health, Medical School University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta
Keywords: Chilhood generalized Epilepsy, Inttractable, Risk factor

Abstract

Introduction: Several datas studied of intractable epilepsy risk factors areavailable in childhood epilepsy. The objectve of this reasearch to investigatethe role of early or evolution several factors on childhood with generalizedepilepsy as risk factors of intractable epilepsy.

Methods: Retrospective cohort study was conducted at neurology out patient pediatric and private outpatient clinic Cipto Mangunkusumo Hospital between January 2010 to December 2013. The inclusion criteria was childhood gener-alized epilepsy with age 1 month up to 18 years old which has been treated with anti epileptic drugs for at least 6 months. Risk factors were analyzed with bivariate and multivariate analysis.

Results: Prevalence of intractable generalized epilepsy is 21% of 102 subject. Bivariate analysis showed that age onset of seizure, initial seizure frequency,non-responder of early treatment, unfavorable gross motor development evo-lution and unfavorable epilepti form EEG evolution were significantly associ-ated with intractable epilepsy. Based on multivariate analysis only non-re-sponder of early treatment (p<0.001) and age onset < 1 year old (p<0.001).Conclusions. Non-responder early treatment and age onset of seizure < 1year old are strongly associated with intractable in childhood generalized epi-lepsy.

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Published
2019-10-02
How to Cite
Mangunatmadja, I., Mulyani, D. I., Pardede, S. O., Tridjadja, B., & Wulandari, H. F. (2019). Risk Factor of Intractable in Childhood with Generalized Epilepsy. Journal Of The Indonesian Medical Association, 69(2), 59-65. https://doi.org/10.47830/jinma-vol.69.2-2019-72