Antibacterial Effect of Combination Fosfomycin and Sulbactam-Cefoperazone against Pseudomonas aeruginosa Bacteria

Antibacterial Effect of Combination Fosfomycin and Sulbactam-Cefoperazone against Pseudomonas aeruginosa Bacteria

  • Agus Syahrurachman Departemen Mikrobiologi Klinik Fakultas Kedokteran Universitas Indonesia
  • Fera Ibrahim Departemen Mikrobiologi Klinik Fakultas Kedokteran Universitas Indonesia
  • Atna Permana Rumah Sakit Haji Jakarta
Keywords: In vitro antibacterial effects, pseudomonas, aeruginosa,fosfomycin, sulbactam-cefoperazone

Abstract

Introduction: Pseudomonas aeruginosa may cause infections in various organs. Due to increase resistance, single antibiotic option for treatment of those infections is more limited.
Objective: to elcucidate in vitro antibacterial effect of fosfomycin and sulbactam-cefoperazone alone and its combination against clinical isolates of Pseudomonas aeruginosa
Methods: Minimal Inhibitory concentration of fosfomycin and cefoperazone-sulbactam as a single drug and their combination was determined in liquid media against 30 clinical isolates of the Pseudomonas aeruginosa. Effect of antibiotic combination was calculated by Fraction Inhibitory Index. Time-kill curve was plotted according to the number of viable bacteria after antibiotic exposure.
Results: The proportion of susceptible isolate to sulbactam-cefoperazon alone was 66.7% and increased to 90 % to combined antibiotics. Proportion of susceptible bacteria to fosfomycin alone was 10 % and increase to 20 % to combined antibiotics. Synergistic, indifferent and antagonistic effects were found in 60%,36.7% and 3.3% strains respectively. Rapid bacterial death occurred within the first 4 hours of exposure.
Conclusion : Combination of sulbactam-cepoferazone and fosfomycin have sinergism in majority of tested strain of Ps aeruginosa and only one strain show antagonistic effect.

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Published
2020-03-13
How to Cite
Agus Syahrurachman, Fera Ibrahim, & Atna Permana. (2020). Antibacterial Effect of Combination Fosfomycin and Sulbactam-Cefoperazone against Pseudomonas aeruginosa Bacteria. Journal Of The Indonesian Medical Association, 69(12), 338-343. https://doi.org/10.47830/jinma-vol.69.12-2019-164