Psychoneuroimmunological Aspect of Type 2 Diabetes Mellitus

  • Ariana Setiani Program Studi Pendidikan Dokter Spesialis Kedokteran Jiwa, Universitas Sebelas Maret, Surakarta
  • Gusti Ayu Maharatih Departemen Ilmu Kedokteran Jiwa, RSUD DR Moewardi, Surakarta
  • Supriyanto Kartodarsono Divisi Endokrin Metabolik Departemen Ilmu Penyakit Dalam, RSUD DR Moewardi, Surakarta
Keywords: type 2 diabetes mellitus, distres psikis, Psikoendokrinoneuroimunologi


Diabetes is a chronic disease which included in the 10 major leading causes of death globally. Pathogenesis of DM 2 involves complex mechanisms in various organs. Psychological conditions including stress, anxiety, and depression considered to be reciprocally related to impaired glucose regulation. On the other hand, hyperglycaemia in DM 2 may triggers some psychological disorder. Chronic psychological disorders activate the HPA axis, causing cortisol level elevation and disrupt its negative feedback mechanism. Other factors involved in disturbance of glucose regulation due to psychological distress were sympathetic nervous system, inflammatory and oxidative stress pathways, tryptophan metabolism and gut microbiota dysbiosis. These factors were interrelated to form a vicious cycle causing progression and complications in DM 2.


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How to Cite
Setiani, A., Maharatih, G. A., & Kartodarsono, S. (2022). Psychoneuroimmunological Aspect of Type 2 Diabetes Mellitus. Journal Of The Indonesian Medical Association, 72(5), 207 - 210.