Profil of Toxigenic Corynebacterium diphtheriae Isolate in East Java, 2012-2017

  • Sugi Deny Pranoto Soegianto Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
  • Adi Pramono Hendrata Balai Besar Laboratorium Kesehatan Daerah (BBLK), Surabaya
  • Eveline Irawan Balai Besar Laboratorium Kesehatan Daerah (BBLK), Surabaya
  • Ismoedijanto Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya
  • Dominicus Husada Department of Child Health, Faculty of Medicine Universitas Airlangga/ Dr. Soetomo General Hospital, Surabaya
Keywords: Corynebacterium diphtheriae, Toxigenic, Profile, East java

Abstract

Introduction: Diphtheria has been reported as an outbreak in some regions inIndonesia, most of the cases are from East Java.Objective: To describe the profile of toxigenic Corynebacterium diphtheriaeisolates in East Java.

Methods. An descriptive study from August 20th -November 30th, 2018. Isolates was selected by cluster random sampling. The viability and toxigenicity testwere done in BBLK Surabaya. Viable and toxigenic isolates were done forcharacteristic analysis.

Result: A total of 114 isolates, 6 were non-viable, 108 were viable and toxi-genic. The majority of the hosts were male (58,3%), median age 6,5-year-old(minimum 1, maximum 14-year-old), 50% from the 1-5-year-old age group. Highest origin of isolates from patients (78,7%) rather than carriers (21,3%).The most isolates from Madura (47,2%) and horseshoe area (20,4%). Most ofthem (74.1%) were taken from a pharyngeal swab rather than a nasal swab(25,4%). Mitis was 76,9% and gravis was 23,1%.

Conclusion: In this study, the majority of toxigenic Corynebacterium diphtheriae were found in the 1-5-year-old age group and most of them domi-cile in Madura and horseshoe area. Most of the isolates were taken from apharyngeal swab of patients. Mitis was the major variant.

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Published
2019-10-02
How to Cite
Soegianto, S. D. P., Hendrata, A. P., Irawan, E., Ismoedijanto, & Husada, D. (2019). Profil of Toxigenic Corynebacterium diphtheriae Isolate in East Java, 2012-2017. Journal Of The Indonesian Medical Association, 69(2), 78-82. https://doi.org/10.47830/jinma-vol.69.2-2019-75
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