PaO2, SaO2, and PaO2/FiO2 Ratio as A Predictor Disease Severity in Hospitalized COVID-19 Patients
Introduction: Currently COVID-19 continues to show an increase in prevalence and mortality. Fever, dry cough, fatique and progression to dyspnea even respiratory failure and ARDS are the symptoms of COVID-19. “Happy hypoxia” is an indication that certain patients do not express breathlessness but have impaired oxygenation. It is important to determine the degree of oxygenation an all COVID-19 patients that will predict the severity of the disease and provide an outline of further management plans.Objective: This study aimed to describe the parameters of blood gas analysis in hospitalized patients and analyze its correlation with degree of severity of the disease
Methods: We conducted observational analysis, cross sectional, single-center study including 71 laboratory-confirmed patients in Dr. Saiful Anwar General Hospital, Malang, Indonesia from April-Juni 2020. Statistical analysis was performed to determine the determine the relation of blood gas analysis with disease severity.
Result: Subjects were divided to 25 patients (35,21%) in the mild-moderate group and 46 patients (64,79%) in severe group. Analysis of demographic and clinical characteristic showed that age, history of smoking, dyspnea and oxygen delivery were associated with disease severity (p<0,005). Statistical analysis of blood gas analysis showed associated degree of oxygenation with disease severity which is assessed by PaO2, SaO2 BGA, PaO2/FiO2 and original PaO2 (p<0,005).
Conclusion: In our cross sectional study we found that degree of oxygenation was associated with disease severity in hospitalized COVID-19 patients.