TY - JOUR AU - Febyan Febyan AU - Soroy Lardo PY - 2020/04/09 Y2 - 2024/03/29 TI - Concept on Series Pathogenesis of Ventilator-Associated- Pneumonia in Intensive Care Unit JF - Journal Of The Indonesian Medical Association JA - J Indon Med Assoc VL - 68 IS - 12 SE - Literature Review DO - 10.47830/jinma-vol.68.12-2018-209 UR - https://mki-ojs.idionline.org/jurnal/article/view/209 AB - Severe sepsis is sepsis with one or more organ dysfunction. One of the causes of sepsis in Intensive Care Unit (ICU) is Hospital-Acquired Pneumonia (HAP). HAP occurs 5-10 cases per 1000 patients on mechanical ventilation. Ventilator Associated Pneumonia (VAP) is predominantly caused by Pseudomonas aeruginosa. Several important factors in the pathogenesis of VAP are barrier to Na+-K+-Cl– transporter-1 (NKCC1), endotracheal tube device without antibiofilm. VAP can be prevented by oral hygiene, endotracheal tube device made from antibiofilm, head up 30 degrees, evaluation of cough ability, swallowing function ER -