@article{Syahrurachman_Ibrahim_Atna Permana_2020, title={Antibacterial Effect of Combination Fosfomycin and Sulbactam-Cefoperazone against Pseudomonas aeruginosa Bacteria}, volume={69}, url={https://mki-ojs.idionline.org/jurnal/article/view/164}, DOI={10.47830/jinma-vol.69.12-2019-164}, abstractNote={<p><em><strong>Introduction:</strong> Pseudomonas aeruginosa may cause infections in various organs. Due to increase resistance, single antibiotic option for treatment of those infections is more limited.</em><br><em><strong>Objective:</strong> to elcucidate in vitro antibacterial effect of fosfomycin and sulbactam-cefoperazone alone and its combination against clinical isolates of Pseudomonas aeruginosa</em><br><em><strong>Methods:</strong> Minimal Inhibitory concentration of fosfomycin and cefoperazone-sulbactam as a single drug and their combination was determined in liquid media against 30 clinical isolates of the Pseudomonas aeruginosa. Effect of antibiotic combination was calculated by Fraction Inhibitory Index. Time-kill curve was plotted according to the number of viable bacteria after antibiotic exposure.</em><br><em><strong>Results:</strong> The proportion of susceptible isolate to sulbactam-cefoperazon alone was 66.7% and increased to 90 % to combined antibiotics. Proportion of susceptible bacteria to fosfomycin alone was 10 % and increase to 20 % to combined antibiotics. Synergistic, indifferent and antagonistic effects were found in 60%,36.7% and 3.3% strains respectively. Rapid bacterial death occurred within the first 4 hours of exposure.</em><br><em><strong>Conclusion :</strong> Combination of sulbactam-cepoferazone and fosfomycin have sinergism in majority of tested strain of Ps aeruginosa and only one strain show antagonistic effect.</em></p&gt;}, number={12}, journal={Journal Of The Indonesian Medical Association}, author={Syahrurachman, Agus and Ibrahim, Fera and Atna Permana}, year={2020}, month={Mar.}, pages={338-343} }